Among dietary supplements for senior dogs, resveratrol and quercetin stand out due to their strong antioxidant, anti-inflammatory properties, and potential role in cancer prevention. Found in natural plant sources such as grapes, berries, onions, and citrus fruits, they provide valuable support in combating health issues that often arise with age in dogs.
Resveratrol – a potential 'elixir of youth'
Resveratrol is a polyphenol found in grape skins, berries, nuts, and red wine. Its antioxidant and anti-inflammatory properties are widely studied in the context of longevity, heart health, and cancer prevention.
In studies on dogs, resveratrol has shown potential in protecting against oxidative stress, which is one of the main mechanisms leading to cell aging. Oxidative stress arises from an excess of free radicals that damage cellular structures, including DNA, proteins, and lipids. This damage can accelerate aging processes and promote the development of many diseases, including cancer.
In studies on animal models, resveratrol has proven effective in slowing down cell degeneration by activating genes responsible for DNA repair and increasing resistance to oxidative stress. In dogs, especially those of older age, resveratrol may help protect against chronic inflammatory diseases such as arthritis, heart disease, and also reduce the risk of cancer.
Mechanism of action of resveratrol
Resveratrol works by activating so-called sirtuins – a group of proteins that regulate aging processes, DNA repair, and metabolism. The most well-known of these proteins, SIRT1, has the ability to extend cell lifespan and also supports regenerative processes in organisms. Resveratrol contributes to the activation of SIRT1, which may lead to improved heart health, maintenance of vascular health, and reduced risk of metabolic diseases.
Moreover, resveratrol exhibits anti-inflammatory properties, which is significant for older dogs that may struggle with inflammatory diseases of the joints, digestive system, as well as chronic infections. Regular use of resveratrol in a senior dog's diet may therefore support tissue regeneration and reduce inflammation in the body.
Research also suggests that resveratrol may support brain functions by protecting nerve cells from damage, which is particularly important for dogs showing signs of senile dementia (Canine Cognitive Dysfunction). It supports neuroprotective processes, helping to maintain cognitive functions and delay brain degeneration.
Quercetin – a strong antioxidant with anti-cancer potential
Quercetin is one of the most powerful natural antioxidants, found in many plants such as onions, apples, berries, citrus fruits, and green tea. Its anti-inflammatory and antioxidant properties are well documented, and an increasing number of studies indicate its potential in fighting cancer and other chronic diseases, especially in older dogs.
Quercetin acts as a blocker of free radical activity and prevents their damaging effects on cells. As an antioxidant, quercetin neutralizes free radicals, preventing oxidative processes and DNA damage, which is crucial in cancer prevention.
In vitro studies have shown that quercetin can inhibit the development of cancer cells, especially in cancers related to the digestive system, including colorectal cancer and liver cancer. Studies in dogs suggest that quercetin supplementation may aid in the healing process and prevent the development of tumors in older animals that are more susceptible to such conditions.
Quercetin also has anti-inflammatory properties, which is why it may be helpful in combating chronic inflammatory conditions that often occur in senior dogs, such as arthritis, heart disease, or respiratory diseases. Due to its ability to regulate histamine levels, quercetin may also support the dog's immune system, reducing allergy symptoms.
Mechanism of action of quercetin
Quercetin acts on various cellular mechanisms, including:
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Inhibition of the activity of inflammatory enzymes, such as COX-2 and 5-LOX, which are responsible for the production of prostaglandins and leukotrienes associated with inflammatory processes.
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Neutralization of free radicals and reduction of oxidative stress, which prevents cell damage.
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Inhibition of angiogenesis, the process of forming new blood vessels, which is crucial in the development of tumors.
Quercetin also supports the detoxification of the body, helping to eliminate harmful substances and toxins, which is important, especially in older dogs whose liver and kidneys may be less efficient in removing toxins.
Supplementation of resveratrol and quercetin in senior dogs
Incorporating resveratrol and quercetin into the diet of senior dogs can be an effective health prevention strategy. Both of these compounds exhibit strong anti-inflammatory, antioxidant, and anti-cancer properties, which is particularly important in the context of health issues affecting older dogs. Supplementation of these compounds may help with:
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Protecting cells from oxidative stress, which accelerates aging processes,
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Supporting heart and joint health,
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Cancer prevention, reducing the risk of cancer occurrence,
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Improving cognitive functions, which is crucial in the fight against dementia in senior dogs
